Alnylam Assist™: Getting Started

Hi, I’m Natalie

Your Local Case Manager

I’m here to personally help you get started with Alnylam Assist™. See below for how to begin.

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Monday - Friday, 8am - 6pm

What You Will Need to Get Started

When you and your doctor choose to begin treatment with AMVUTTRA® (vutrisiran) and to enroll in Alnylam Assist™, the next step is to complete the Start Form together.

Before you begin this process with your doctor, please take a few minutes to review the types of information you will need to fill out for your sections of the Start Form, especially if you have additional information you need to provide for a loved one:

Personal Information

Personal Information

This includes basic information like your name, date of birth, current mailing address, email, and phone number.

Alnylam Assist® - Understanding Your Benefits

Primary Insurance Information

This includes information found on your insurance card, if you have one. You will need your plan name, policy number, and group number, so be sure to have your insurance card available.

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Physician Information

In order to get started with Alnylam Assist™, your doctor is required to initiate your enrollment in the program and provide their information.

How to Begin the Start Form

The first step towards getting started with Alnylam Assist™ is to complete the Start Form with your doctor.

Your doctor has options on how to do this. Doctors will either 1) complete the form with you present, or 2) begin the form by filling out their physician information, then share with you via email to complete your portion.

Then, your doctor will submit the form to Alnylam Assist™. Upon receipt of the Start Form, an Alnylam Case Manager will reach out to you and your doctor within 2 business days.

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Want to learn more about AMVUTTRA?

Visit the AMVUTTRA patient website

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What is the Alnylam Assist™ program?

The Alnylam Assist™ program offers you support throughout your treatment with an Alnylam product. This includes helping you understand your insurance coverage for your treatment and the options for financial support for which you may be eligible. Alnylam Assist will also provide materials that may help start conversations with your doctor and family about your treatment. See the support available. See all of the support available ›

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Find answers to other

Frequently Asked Questions ›

Alnylam Assist® Case Manager Natalie

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Monday - Friday, 8am - 6pm


What are the most important things I should know about AMVUTTRA® (vutrisiran)?

AMVUTTRA can cause:

Low Vitamin A Levels

Treatment with AMVUTTRA lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.

Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking AMVUTTRA, talk to your doctor. Your doctor may refer you to an eye specialist.

What are the common side effects of AMVUTTRA?

The most common side effects of AMVUTTRA are pain in the joints (arthralgia), shortness of breath (dyspnea), and low vitamin A levels.

These are not all the possible side effects of AMVUTTRA. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the U.S. Food and Drug Administration (FDA). Visit, or call 1-800-FDA-1088.


What is AMVUTTRA® (vutrisiran)?

AMVUTTRA is a prescription medicine that treats the polyneuropathy caused by an illness called hereditary transthyretin‑mediated amyloidosis (hATTR amyloidosis). AMVUTTRA is used in adults only.

For additional information about AMVUTTRA, please see the full Prescribing Information.