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How Alnylam Assist™ Can Help Your Patients

Alnylam Assist™ will be there for your patients throughout treatment with GIVLAARI® (givosiran). Ready to enroll your patient?

Enroll Now

Alnylam Assist™ Services Overview

Upon receipt of the Start Form, an Alnylam Case Manager dedicated to your patient’s needs will reach out to you and your patient within 1-2 business days. Your patient’s Case Manager will help with the following:

Alnylam Assist® - Benefit Verification
Benefit Verification

Help determine patient-specific coverage requirements, which include the following:

Initiate a benefit verification for your patient and provide you and your patient with a benefit verification summary

Provide information about patient financial assistance programs for eligible patients,a if necessary

Alnylam Assist® - Treatment Coverage
Treatment Coverage

Explain the requirements and processes for prior authorizations, claims, and appeals, which include the following:

Research the payer requirements as part of the benefit verification process

Discuss the standard process for submitting a prior authorization and reimbursement claims

Investigate reasons for denied or rejected prior authorizations, claims, and/or appeals

Alnylam Assist® - Financial Assistance
Financial Assistance

Review financial assistance programs your patient may qualify for based on his or her eligibility. Select patients may qualify for the following financial assistance programsa b:

Patient Assistance Program (PAP): Provides GIVLAARI at no cost to eligible patients

Commercial Copay Program: Covers out-of-pocket medication costs for eligible patients

Alnylam Assist® - Disease and Product Education
Disease and Product Education

Provide information to your patients:

A Patient Starter Kit, including educational materials designed to help patients understand GIVLAARI and Alnylam Assist™

Education for your patients from a designated Alnylam Patient Education Liaison (PEL) to help them gain a better understanding of acute hepatic porphyria and treatment with GIVLAARI. PELs are employees of Alnylam Pharmaceuticals and do not provide medical advice.

Alnylam Assist® - Facilitation of Product Orders
Facilitation of Product Orders

a  Alnylam reserves the right to make eligibility determinations and to modify or discontinue any program at any time.

b  Patients with Medicare, Medicaid, or other government-sponsored insurance are not eligible for the Alnylam Assist™ Commercial Copay Program. Out-of-pocket costs for the administration of GIVLAARI will not be covered for patients residing where it is prohibited by law or where otherwise restricted.

Alnylam Field Reimbursement Directors

Alnylam Field Reimbursement Directors (FRDs) are available to provide education about the GIVLAARI reimbursement process. FRDs will share their knowledge of:

GIVLAARI billing and coding requirements

Chart documentation requirements

Payer requirements

Download Brochures and Guides

Healthcare Professionals

Alnylam Assist™ Services

Overview Brochure (PDF)

Alnylam Assist® Services Overview Brochure for HCPs Thumbnail - for GIVLAARI® (givosiran)


Patients + Caregivers

Alnylam Assist™ Brochure (PDF)


Alnylam Assist® Brochure for Patients Thumbnail - for GIVLAARI® (givosiran)


Where can I find the necessary forms and documents to enroll patients in Alnylam Assist™?

Alnylam Assist™ provides all the required forms and documents to enroll your patients, as well as downloadable educational resources. View the associated GIVLAARI forms and documents ›

Alnylam Assist® - FAQ

Find answers to other

Frequently Asked Questions ›

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Together with your patient
(in office)

Alnylam Assist® electronic Start Form icon

Electronic Start Form

Begin Here ›


Alnylam Assist® Start Form - To Print And Fax

& Fax

Download Form ›

Initiate then send to patient
(via email)

Alnylam Assist® Start Form - To Email To Patient

DocuSign eSignature

Begin Here ›

HCP triangle



GIVLAARI® (givosiran) is contraindicated in patients with known severe hypersensitivity to givosiran. Reactions have included anaphylaxis.

Anaphylactic Reaction

Anaphylaxis has occurred with GIVLAARI treatment (<1% of patients in clinical trials). Ensure that medical support is available to appropriately manage anaphylactic reactions when administering GIVLAARI. Monitor for signs and symptoms of anaphylaxis. If anaphylaxis occurs, immediately discontinue administration of GIVLAARI and institute appropriate medical treatment.

Hepatic Toxicity

Transaminase elevations (ALT) of at least 3 times the upper limit of normal (ULN) were observed in 15% of patients receiving GIVLAARI in the placebo-controlled trial. Transaminase elevations primarily occurred between 3 to 5 months following initiation of treatment.

Measure liver function tests prior to initiating treatment with GIVLAARI, repeat every month during the first 6 months of treatment, and as clinically indicated thereafter. Interrupt or discontinue treatment with GIVLAARI for severe or clinically significant transaminase elevations. In patients who have dose interruption and subsequent improvement, reduce the dose to 1.25 mg/kg once monthly. The dose may be increased to the recommended dose of 2.5 mg/kg once monthly if there is no recurrence of severe or clinically significant transaminase elevations at the 1.25 mg/kg dose.

Renal Toxicity

Increases in serum creatinine levels and decreases in estimated glomerular filtration rate (eGFR) have been reported during treatment with GIVLAARI. In the placebo-controlled study, 15% of patients receiving GIVLAARI experienced a renally-related adverse reaction. The median increase in creatinine at Month 3 was 0.07 mg/dL. Monitor renal function during treatment with GIVLAARI as clinically indicated.

Injection Site Reactions

Injection site reactions were reported in 25% of patients receiving GIVLAARI in the placebo-controlled trial. Symptoms included erythema, pain, pruritus, rash, discoloration, or swelling around the injection site. One (2%) patient experienced a single, transient, recall reaction of erythema at a prior injection site with a subsequent dose administration.

Blood Homocysteine Increased

Increases in blood homocysteine levels have occurred in patients receiving GIVLAARI. In the ENVISION study, during the open label extension, adverse reactions of blood homocysteine increased were reported in 15 of 93 (16%) patients treated with GIVLAARI. Measure blood homocysteine levels prior to initiating treatment and monitor for changes during treatment with GIVLAARI. In patients with elevated blood homocysteine levels, assess folate, vitamins B12 and B6. Consider treatment with a supplement containing vitamin B6 (as monotherapy or a multivitamin preparation).

Drug Interactions

Concomitant use of GIVLAARI increases the concentration of CYP1A2 or CYP2D6 substrates, which may increase adverse reactions of these substrates. Avoid concomitant use of GIVLAARI with CYP1A2 or CYP2D6 substrates for which minimal concentration changes may lead to serious or life-threatening toxicities. If concomitant use is unavoidable, decrease the CYP1A2 or CYP2D6 substrate dosage in accordance with approved product labeling.

Adverse Reactions

The most common adverse reactions that occurred in patients receiving GIVLAARI were nausea (27%) and injection site reactions (25%).


GIVLAARI® is indicated for the treatment of adults with acute hepatic porphyria (AHP).

For additional information about GIVLAARI, please see the full Prescribing Information.