Alnylam Assist™: Personalized Support

Hi, I’m Natalie

Your Dedicated Case Manager

I’m here to personally help you get started with Alnylam Assist™. See below for how to begin.

Call me now to get started


Monday - Friday, 8am - 6pm ET

What You Will Need to Get Started

When you and your doctor choose to begin treatment with ONPATTRO® (patisiran), the first step is to complete the Start Form together.

Before you begin this process with your doctor, please take a few minutes to review the types of information you will need to fill out for your sections of the Start Form, especially if you have additional information you need to provide for a loved one:

Personal Information

Personal Information

This includes basic information like your name, date of birth, current mailing address, email, and phone number.

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Primary Insurance Information

This includes information found on your insurance card, if you have one. You will need your plan name, policy number, and group number, so be sure to have your insurance card available.

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Physician Information

In order to get started with Alnylam Assist™, your doctor is required to initiate your enrollment in the program and provide their information.

How to Begin the Start Form

The first step towards getting started with the program is to complete the Start Form with your doctor.

Your doctor has options on how to do this. Doctors will either 1) complete the form with you present, or 2) begin the form by filling out their physician information, then share with you via email to complete your portion.

Then, your doctor will submit the form to Alnylam Assist™. Upon receipt of the Start Form, your dedicated Alnylam Case Manager will reach out to you and your doctor within 1-2 business days.

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Want to learn more about ONPATTRO?

Visit the ONPATTRO patient website

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What is the Alnylam Assist™ program?

Alnylam Assist™ is a comprehensive patient support program that offers truly personalized assistance to patients getting started on treatment with ONPATTRO or other Alnylam products. See all of the support available ›

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Find answers to other

Frequently Asked Questions ›

Alnylam Assist® Case Manager Natalie

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Monday - Friday,
8am - 6pm ET

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What are the most important things I should know about ONPATTRO® (patisiran)?

ONPATTRO can cause:

Infusion-related reactions

ONPATTRO is given as a drip into a vein (called an “intravenous infusion”). Reactions to this infusion may happen during treatment with ONPATTRO. Before each infusion you will be given medicines that help to lower the chance of infusion-related reactions.

Tell your doctor or nurse right away if you experience any of the following signs of an infusion-related reaction during treatment:

Reddening of the face or body (flushing), skin warm
  Body aches or pain, including pain in the back, neck, or joints
  Feeling sick (nausea)
  Stomach pain
  Feeling short of breath, cough, or other breathing problems
  Chest discomfort or chest pain
  Feeling tired (fatigue)
  Rapid heart rate
  Facial swelling

If you have an infusion-related reaction, your doctor or nurse may slow down or stop your infusion, and you may need to take other medicines. When these reactions stop, or get better, your doctor or nurse may decide to start the infusion again.

Low Vitamin A levels

Treatment with ONPATTRO lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.

Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking ONPATTRO, talk to your doctor. Your doctor may refer you to an eye specialist.

What are the common side effects of ONPATTRO?

The most common side effects of ONPATTRO are respiratory infections, such as colds, sinus infections, and nasal congestion, and infusion-related reactions. These are not all the possible side effects of ONPATTRO. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.



ONPATTRO is a prescription medicine that treats the polyneuropathy caused by an illness called hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis). ONPATTRO is used in adults only.

For additional information about ONPATTRO, please see the full Prescribing Information.