am -
pm ET

Let’s Work Together

Alnylam Assist™ knows how important one-on-one interactions are, which is why we have dedicated Case Managers and Patient Education Liaisons (PELs) for each patient to provide ongoing education, tools to connect with the community, and resources that can help you during treatment. Starting a new routine can be daunting, but you don't have to do it alone.

Alnylam Assist® Case Managers

Case Managers

Once you and your doctor choose to start treatment with ONPATTRO® (patisiran), you will be partnered with a dedicated Alnylam Case Manager. Case Managers are trained professionals whose expertise is in helping patients get started on treatment and providing ongoing support. They will tailor their level of contact based on your personal needs.

Your Case Manager will help you understand your insurance coverage benefits and verify them for you. They can also inform you about financial support that you may be eligible for as well as provide you with educational resources. In addition, Case Managers can connect you with a PEL by request.

Alnylam Assist® Case Manager Natalie

Meet Your Case ManagerRead Natalie's Bio ›

Alnylam Assist® Patient Education Liaisons

Patient Education Liaisons

Your Case Manager also can help connect you with a Patient Education Liaison (PEL). PELs have backgrounds in nursing, and are experienced in educating people and their families about matters related to hATTR amyloidosis. Your PEL can help you in a variety of ways, such as:

Supporting you with disease education

Providing you with product information

Connecting you to additional resources

Answering questions about treatment with ONPATTRO

In addition, PELs help facilitate educational events about hATTR amyloidosis in communities around the United States. Talk to your Case Manager about finding an event in your area, or request a conversation with a PEL. Talk to a PEL ›

The purpose of Alnylam Patient Education Liaisons (PELs) is to provide education to patients, their families, and caregivers

PELs are employees of Alnylam Pharmaceuticals; They are not acting as healthcare providers and are not part of your healthcare team

PELs do not provide medical care or advice

All diagnosis and treatment decisions should be made by you and your doctor

What additional resources does Alnylam Assist™ offer?

Downloadable educational materials about hATTR amyloidosis and treatment, as well as links to advocacy groups that connect patients to the hATTR amyloidosis community. Find additional resources ›

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Frequently Asked Questions ›

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See How to Get Started

Once you and your doctor decide to begin treatment with ONPATTRO, we'll work with your healthcare team to start the process.

How to Get Started

Alnylam Assist® Case Manager Natalie

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Monday - Friday,
8am - 6pm ET

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What are the most important things I should know about ONPATTRO® (patisiran)?

ONPATTRO can cause:

Infusion-related reactions

ONPATTRO is given as a drip into a vein (called an “intravenous infusion”). Reactions to this infusion may happen during treatment with ONPATTRO. Before each infusion you will be given medicines that help to lower the chance of infusion-related reactions.

Tell your doctor or nurse right away if you experience any of the following signs of an infusion-related reaction during treatment:

Reddening of the face or body (flushing), skin warm
  Body aches or pain, including pain in the back, neck, or joints
  Feeling sick (nausea)
  Stomach pain
  Feeling short of breath, cough, or other breathing problems
  Chest discomfort or chest pain
  Feeling tired (fatigue)
  Rapid heart rate
  Facial swelling

If you have an infusion-related reaction, your doctor or nurse may slow down or stop your infusion, and you may need to take other medicines. When these reactions stop, or get better, your doctor or nurse may decide to start the infusion again.

Low Vitamin A levels

Treatment with ONPATTRO lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.

Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking ONPATTRO, talk to your doctor. Your doctor may refer you to an eye specialist.

What are the common side effects of ONPATTRO?

The most common side effects of ONPATTRO are respiratory infections, such as colds, sinus infections, and nasal congestion, and infusion-related reactions. These are not all the possible side effects of ONPATTRO. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.



ONPATTRO is a prescription medicine that treats the polyneuropathy caused by an illness called hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis). ONPATTRO is used in adults only.

For additional information about ONPATTRO, please see the full Prescribing Information.