Alnylam Assist®—Your Dedicated Support Team

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Alnylam Assist® is dedicated to providing the best treatment experience possible for patients taking ONPATTRO® (patisiran). The Team is here to do just that—from helping you understand benefits coverage to providing financial assistance for eligible patients, and much more.

Case Managers

Once you decide to start treatment with ONPATTRO® (patisiran), you will be partnered with your own personal Alnylam Case Manager. Case Managers are experienced in helping individuals get started on treatment and providing ongoing support. They will tailor their level of contact based on your personal needs.

Your Case Manager can help you understand your insurance coverage and your options for financial support that you may be eligible for as well as provide you with educational resources.

You also can look to your Case Manager to provide information about infusion centers nearest to you as well as information on transitioning to home infusions if you and your doctor decide that it is right for you. Please note that home infusions may not be covered by all insurance plans.

Patient Education Liaisons

Your Case Manager also can help connect you with a Patient Education Liaison (PEL). PELs are available to meet with you in person or talk to you by phone. Reach out to your Case Manager to learn more about how to contact a PEL.

PELs have backgrounds in nursing or genetic counseling, and are experienced in educating individuals and their families about matters related to hereditary ATTR (hATTR) amyloidosis. PELs can help you in a variety of ways, including providing disease and product education, connecting you to additional resources, and answering questions about treatment.

PELs help raise awareness about hATTR amyloidosis in the community and educate patients and their families. They engage with patients 1:1 to provide education, participate in family meetings, and reach out to community health organizations and advocacy groups.

PELs help facilitate educational events about hATTR amyloidosis in communities around the United States. Talk to your Case Manager about finding an event in your area.

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Important Safety Information

What are the most important things I should know about ONPATTRO® (patisiran)?

ONPATTRO can cause:

• Infusion-related reactions

ONPATTRO is given as a drip into a vein (called an “intravenous infusion”). Reactions to this infusion may happen during treatment with ONPATTRO. Before each infusion you will be given medicines that help to lower the chance of infusion-related reactions.

What are the most important things I should know about ONPATTRO® (patisiran)?

ONPATTRO can cause:

• Infusion-related reactions

Tell your doctor or nurse right away if you experience any of the following signs of an infusion-related reaction during treatment:

• Reddening of the face or body (flushing), skin warm
• Body aches or pain, including pain in the back, neck, or joints
• Feeling sick (nausea)
• Stomach pain
• Feeling short of breath, cough, or other breathing problems
• Headache
• Chest discomfort or chest pain
• Rash
• Chills
• Dizziness
• Feeling tired (fatigue)
• Rapid heart rate
• Facial swelling

If you have an infusion-related reaction, your doctor or nurse may slow down or stop your infusion, and you may need to take other medicines. When these reactions stop, or get better, your doctor or nurse may decide to start the infusion again.

• Low Vitamin A levels

Treatment with ONPATTRO lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.

Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking ONPATTRO, talk to your doctor. Your doctor may refer you to an eye specialist.

What are the common side effects of ONPATTRO?

The most common side effects of ONPATTRO are respiratory infections, such as colds, sinus infections, and nasal congestion, and infusion-related reactions. These are not all the possible side effects of ONPATTRO. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Indication

What is ONPATTRO?

ONPATTRO is a prescription medicine that treats the polyneuropathy caused by an illness called hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis). ONPATTRO is used in adults only.

For additional information about ONPATTRO, please see the full Prescribing Information.

Important Safety Information

What are the most important things I should know about ONPATTRO® (patisiran)?

ONPATTRO can cause:

• Infusion-related reactions

Tell your doctor or nurse right away if you experience any of the following signs of an infusion-related reaction during treatment:

• Low Vitamin A levels

Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking ONPATTRO, talk to your doctor. Your doctor may refer you to an eye specialist.

What are the common side effects of ONPATTRO?

Indication

What is ONPATTRO?

ONPATTRO is a prescription medicine that treats the polyneuropathy caused by an illness called hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis). ONPATTRO is used in adults only.