am -
pm ET

Resources for Patients and Their Families

We have provided some resources about Alnylam Assist™ and treatment with AMVUTTRA® (vutrisiran). In addition, we’ve included some organizations that provide community support and educational materials for those affected by hATTR amyloidosis.

The Team at a Glance

Alnylam Assist® Case Managers

After you and your doctor decide to begin AMVUTTRA and enroll in Alnylam Assist™, we can provide support in 3 key areas:

Understanding Benefits

Eligibility For Financial Assistance

Disease and Product Education

Alnylam Assist® - Downloadable PDF

Alnylam Assist™ Brochure


Alnylam Assist™ - FAQ Icon

Alnylam Assist™ FAQs

Visit FAQs Page

AMVUTTRA® Resources

Explore the resources below to learn about treatment with AMVUTTRA.

Alnylam Assist® - Downloadable PDF

AMVUTTRA® (vutrisiran) Brochure

This brochure helps educate and inform you and your loved ones about the polyneuropathy of hATTR amyloidosis, describes how hATTR amyloidosis affects your body, and shows results from an AMVUTTRA clinical study.

Download PDF

Insurance Resources

Alnylam Assist™ provides resources to help patients access therapy throughout the treatment journey.


out-of-pocket cost for AMVUTTRA for patients enrolled in Alnylam’s Commercial Copay Program


of U.S. lives have confirmed access to AMVUTTRA across commercial, Medicare, Medicaid, and other government payer categories*

  Patients must meet specified criteria to qualify for assistance. Alnylam reserves the right to make eligibility determinations and to modify or discontinue the program at any time. Limitations may apply.

*  This percentage is an approximation. Coverage may vary for individual and plan. Data as of [June 2022]

Alnylam Assist® - Downloadable PDF

Explanation of Benefits (EOB)

This sheet outlines insurance company EOBs, what information they contain, and how to better understand them.

Download PDF

Alnylam Assist® - Downloadable PDF

Glossary of Insurance Terms

A handy reference glossary to help educate patients and caregivers about common insurance terminology.

Download PDF

Caregiver Resources

Caregivers of people with hATTR amyloidosis can play a vital role in helping support their loved ones throughout treatment. Caregiver resources are designed to help these important individuals.

Alnylam Assist® - Downloadable PDF

Alnylam Assist™ Caregiver Brochure

This brochure was designed to support caregivers of patients with rare diseases by offering best practices and tips on how to talk to the healthcare team and provide self care.

Download PDF

Disease and Advocacy Resources


Amyloidosis Foundation Logo

Amyloidosis Foundation

Foundation whose priorities include raising awareness, educating medical professionals, and empowering patients affected by amyloidosis.


Amyloidosis Research Consortium Logo

Amyloidosis Research Consortium

The Amyloidosis Research Consortium is accelerating the development of effective treatments for systemic amyloidosis through key research, collaboration, and innovation.


Amyloidosis Support Groups Logo

Amyloidosis Support Groups

A website dedicated to support groups for those suffering from amyloidosis and other amyloidosis-related diseases.


Foundation for Peripheral Neuropathy Logo

The Foundation for Peripheral Neuropathy

A public charity foundation that strives to cure painful neuropathies through collaborative research, education, and treatment.


Global Genes Logo

Global Genes

Global Genes is your ally in the fight against rare disease. Global Genes provides helpful resources while sponsoring local and global events to help connect, empower, and inspire the rare disease community.


National Organization for Rare Disorders Logo

National Organization for Rare Disorders

The National Organization for Rare Disorders offers educational videos and interactive webinars along with a variety of additional resources.


For Caregivers

Caregiver Action Network (CAN)

The Caregiver Action Network is the nation's leading family caregiver organization working to improve quality of life for the more than 90 million Americans who care for their loved ones.


National Alliance for Caregiving (NAC)

The National Alliance for Caregiving is a non-profit coalition dedicated to improving quality of life for friend and family caregivers and those in their care, by advancing research, advocacy, and innovation.


How do I get started with Alnylam Assist™?

To get started, you must be prescribed AMVUTTRA and fill out the Start Form with your doctor. Once the form is completed and you’ve signed it, your doctor can submit the form online or print it out and fax it to Alnylam Assist™. Find out how to get started ›

Alnylam Assist® - Questions Icon

Find answers to other

Frequently Asked Questions ›

Alnylam Assist® get started icon

See How to Get Started

Once you and your doctor decide to begin treatment with AMVUTTRA, we'll work with your healthcare team to start the process.

How to Get Started

Alnylam Assist® Case Manager Natalie

Call Natalie


Monday - Friday,
8am - 6pm

Alylam Separator Triangles


What are the most important things I should know about AMVUTTRA® (vutrisiran)?

AMVUTTRA can cause:

Low Vitamin A Levels

Treatment with AMVUTTRA lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.

Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking AMVUTTRA, talk to your doctor. Your doctor may refer you to an eye specialist.

What are the common side effects of AMVUTTRA?

The most common side effects of AMVUTTRA are pain in the joints (arthralgia), shortness of breath (dyspnea), and low vitamin A levels.

These are not all the possible side effects of AMVUTTRA. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the U.S. Food and Drug Administration (FDA). Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.


What is AMVUTTRA® (vutrisiran)?

AMVUTTRA is a prescription medicine that treats the polyneuropathy caused by an illness called hereditary transthyretin‑mediated amyloidosis (hATTR amyloidosis). AMVUTTRA is used in adults only.

For additional information about AMVUTTRA, please see the full Prescribing Information.