ONPATTRO is given as a drip into a vein (called an “intravenous infusion”). Reactions to this infusion may happen during treatment with ONPATTRO. Before each infusion you will be given medicines that help to lower the chance of infusion-related reactions.

Tell your doctor or nurse right away if you experience any of the following signs of an infusion-related reaction during treatment:

– Reddening of the face or body (flushing), skin warm
 – Body aches or pain, including pain in the back, neck, or joints
  – Feeling sick (nausea)
  – Stomach pain
  – Feeling short of breath, cough, or other breathing problems
  – Headache
  – Chest discomfort or chest pain
  – Rash
  – Chills
  – Dizziness
  – Feeling tired (fatigue)
  – Rapid heart rate
  – Facial swelling

If you have an infusion-related reaction, your doctor or nurse may slow down or stop your infusion, and you may need to take other medicines. When these reactions stop, or get better, your doctor or nurse may decide to start the infusion again.

Treatment with ONPATTRO lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.

Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking ONPATTRO, talk to your doctor. Your doctor may refer you to an eye specialist.