Alnylam Assist™: Patient Support Program

Hi, I’m Rachael

Your Local Case Manager

I'm here to support patients throughout their Alnylam treatment experience. I am specifically assigned to work with certain patients on questions they may have about Alnylam Assist™ and ONPATTRO® (patisiran).

Call Rachael:


Monday - Friday, 8am - 6pm

Get Started

How We Can Help

Now that you or your loved one have been prescribed ONPATTRO, Alnylam Assist™ is here to help you access therapy.

Each person is unique - support should be that way too. Alnylam Assist™ will help with accessing treatment and providing education depending on where you are on the treatment journey and will tailor their method of communication to what works best for you.

How We Can Help

Support to Get Started

After you begin treatment with ONPATTRO and enroll, Alnylam Assist™ will provide product support in 3 key areas:

Alnylam Assist® - Understanding Your Benefits
Understanding Your Benefits

Review and verify your insurance benefit coverage for ONPATTRO treatment.

Alnylam Assist® - Financial Assistance Options
Financial Assistance

Alnylam Assist™ provides financial assistance options for qualifying individuals. An Alnylam Case Manager will work with you to determine eligibility.*

*  Patients must meet specified eligibility criteria to qualify for assistance. Alnylam reserves the right to make eligibility determinations and to modify or discontinue any program at any time.

Alnylam Assist® - Disease And Treatment Education
Disease and Product Education

Materials to help educate you and your family on hATTR amyloidosis and treatment.

Support for Your Journey

Alnylam Assist™ can help educate you and your loved ones about hATTR amyloidosis and connect you with advocacy organizations that are involved in the hATTR amyloidosis community.

See More Resources

Our Message to Caregivers

Alnylam Assist™ Caregiver Support Icon

We understand that hATTR amyloidosis can affect more than just one individual

Alnylam Assist™ is here to help your loved one access ONPATTRO® (patisiran) and can provide you with additional resources to learn more about the disease and treatment.

See More Resources

Alnylam Assist® get started icon

See How to Get Started

Once you and your doctor decide to begin treatment with ONPATTRO, we'll work with your healthcare team to start the process.

How to Get Started

Alnylam Assist® Case Manager Rachael

Call Rachael


Monday - Friday,
8am - 6pm

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What are the most important things I should know about ONPATTRO® (patisiran)?

ONPATTRO can cause:

Infusion-related reactions

ONPATTRO is given as a drip into a vein (called an “intravenous infusion”). Reactions to this infusion may happen during treatment with ONPATTRO. Before each infusion you will be given medicines that help to lower the chance of infusion-related reactions.

Tell your doctor or nurse right away if you experience any of the following signs of an infusion-related reaction during treatment:

Reddening of the face or body (flushing), skin warm
  Body aches or pain, including pain in the back, neck, or joints
  Feeling sick (nausea)
  Stomach pain
  Feeling short of breath, cough, or other breathing problems
  Chest discomfort or chest pain
  Feeling tired (fatigue)
  Rapid heart rate
  Facial swelling

If you have an infusion-related reaction, your doctor or nurse may slow down or stop your infusion, and you may need to take other medicines. When these reactions stop, or get better, your doctor or nurse may decide to start the infusion again.

Low Vitamin A levels

Treatment with ONPATTRO lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.

Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking ONPATTRO, talk to your doctor. Your doctor may refer you to an eye specialist.

What are the common side effects of ONPATTRO?

The most common side effects of ONPATTRO are respiratory infections, such as colds, sinus infections, and nasal congestion, and infusion-related reactions. These are not all the possible side effects of ONPATTRO. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.



ONPATTRO is a prescription medicine that treats the polyneuropathy caused by an illness called hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis). ONPATTRO is used in adults only.

For additional information about ONPATTRO, please see the full Prescribing Information.