Alnylam Assist®: Support for Every Step

Hi, I’m Shontae

Your Dedicated Case Manager

I'm here to help you throughout the treatment process and have been specifically assigned to you and others in your area.

Call Me: 1-833-256-2748 | Monday - Friday, 8am - 6pm ET

Get Started

How We Can Help

As you begin your treatment with ONPATTRO® (patisiran), Alnylam Assist® will provide you with ongoing support.

financial assistance options • determining insurance coverage • support materials

How We Can Help

Get more information about Alnylam and ONPATTRO by downloading the brochures below.

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Your Team

Once you decide to start treatment with ONPATTRO, you will be partnered with your own personal Alnylam Case Manager. Case Managers are experienced in helping individuals get started on treatment and providing ongoing support. They will tailor their level of contact based on your personal needs.

Understanding benefits

Your Case Manager will review your insurance coverage and answer any questions about your insurance benefits for ONPATTRO. 

Alnylam Assist® - Financial Assistance Options
Financial assistance

Alnylam Assist® provides financial assistance options for qualifying individuals. Your Case Manager will work with you to determine eligibility.*

Patient Support With Alnylam Assist®
Ongoing support

Our personalized support doesn't stop once you start treatment. We'll continue to provide assistance whenever you need it.

*Individuals must meet specified financial eligibility criteria to qualify for assistance. Alnylam reserves the right to make eligibility determinations and to modify or discontinue the program at any time.

Support For Your Journey

Beyond our own program, there are many resources available to you. Learn more about your condition and join a growing support community.

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Alnylam Assist® - Support Team
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Call Shontae:


Monday - Friday, 8am - 6pm ET

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We’ll help you work with your healthcare professional to begin the process

How to Get Started

Important Safety Information

What are the most important things I should know about ONPATTRO® (patisiran)?

ONPATTRO can cause:

• Infusion-related reactions

ONPATTRO is given as a drip into a vein (called an “intravenous infusion”). Reactions to this infusion may happen during treatment with ONPATTRO. Before each infusion you will be given medicines that help to lower the chance of infusion-related reactions.

Tell your doctor or nurse right away if you experience any of the following signs of an infusion-related reaction during treatment:

• Reddening of the face or body (flushing), skin warm
• Body aches or pain, including pain in the back, neck, or joints
• Feeling sick (nausea)
• Stomach pain
• Feeling short of breath, cough, or other breathing problems
• Headache
• Chest discomfort or chest pain
• Rash
• Chills
• Dizziness
• Feeling tired (fatigue)
• Rapid heart rate
• Facial swelling


If you have an infusion-related reaction, your doctor or nurse may slow down or stop your infusion, and you may need to take other medicines. When these reactions stop, or get better, your doctor or nurse may decide to start the infusion again.

• Low Vitamin A levels

Treatment with ONPATTRO lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.

Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking ONPATTRO, talk to your doctor. Your doctor may refer you to an eye specialist.

What are the common side effects of ONPATTRO?

The most common side effects of ONPATTRO are respiratory infections, such as colds, sinus infections, and nasal congestion, and infusion-related reactions. These are not all the possible side effects of ONPATTRO. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.



ONPATTRO is a prescription medicine that treats the polyneuropathy caused by an illness called hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis). ONPATTRO is used in adults only.

For additional information about ONPATTRO, please see the full Prescribing Information.