Tell your doctor or nurse right away if you experience any of the following signs or symptoms of a severe allergic reaction during treatment:

– Swelling – mainly of the lips, tongue or throat which makes it difficult to swallow or breathe
 – Breathing problems or wheezing
  – Feeling dizzy or fainting
  – Rash or hives
  – Itching

If you have a severe allergic reaction, your doctor or nurse will stop GIVLAARI treatment right away and you may need to take other medicines to control the symptoms.

Your doctor will check your liver function by doing blood tests:

– Before you start using GIVLAARI
  – Once a month for the first 6 months of treatment
  – And when they think it is needed

If these tests show abnormal results, your doctor or nurse will decide whether to temporarily interrupt or stop treatment with GIVLAARI.

Your doctor will check how your kidneys are working while you are using GIVLAARI.

GIVLAARI is given as an injection under the skin (called a “subcutaneous injection”). Reactions to this injection may happen during treatment with GIVLAARI.

Tell your doctor or nurse right away if you experience any of the following symptoms of an injection site reaction during treatment: redness, pain, itchiness, rash, discoloration, or swelling around the injection site.

GIVLAARI may cause increased levels of homocysteine (a type of amino acid) in your blood. Your doctor will check your homocysteine levels before and during treatment by doing blood tests. If your levels are increased, your doctor may check your folate, vitamins B12 and B6, and tell you to take a vitamin B6 supplement.