Alnylam Assist™: Support for Every Step

Hi, I’m Kevin

Your Dedicated Case Manager

I'm here to support you throughout your treatment experience and have been specifically assigned to help you with questions you may have about Alnylam Assist™ and GIVLAARI® (givosiran).

Call Kevin:


Monday - Friday, 8am - 6pm ET

Get Started

How We Can Help

Now that you or your loved one has been diagnosed with acute hepatic porphyria (AHP) and has been prescribed GIVLAARI® (givosiran), Alnylam Assist™ is here to help support you.

Each person is unique—your support should be that way, too. Alnylam Assist™ is designed to be truly personalized: a support team who is easily accessible and adaptable. So if your support needs change during treatment, your level of support can change, too.

How We Can Help

Get the Support You Need

After you begin treatment with GIVLAARI and enroll in Alnylam Assist™, your dedicated Case Manager and the Alnylam Assist™ team will provide ongoing support in 3 key areas:

Alnylam Assist® - Understanding Insurance Benefits
Understanding Your Benefits

Review and verify your insurance benefit coverage for GIVLAARI treatment.

Alnylam Assist™ - Financial Assistance
Financial Assistance Options

Alnylam Assist™ provides financial assistance options for qualifying individuals. Your Case Manager will work with you to determine eligibility.*

*  Patients must meet specified eligibility criteria to qualify for assistance. Alnylam reserves the right to make eligibility determinations and to modify or discontinue any program at any time

Alnylam Assist® - Disease And Treatment Education
Disease and Treatment Education

Materials to help educate you and your family on AHP and treatment.

Support for Your Journey

In addition to personalized support from your Case Manager, Alnylam Assist™ can help educate you and your loved ones about AHP and connect you with advocacy organizations that are involved in the AHP community.

See More Resources

Our Message to Caregivers

Alnylam Assist™ Caregiver Support Icon

We're here to support you the same way you support your loved ones

We understand that support is more than insurance, and you can be affected by AHP, too. Alnylam Assist™ is here to help you navigate the day-to-day treatment experience, while you navigate everything else. Don't worry, you're in the right place.

See More Resources

Alnylam Assist® get started icon

See How to Get Started

Once you and your doctor decide to begin treatment with GIVLAARI, we'll work with your healthcare team to start the process.

How to Get Started

Alnylam Assist® Case Manager Kevin

Call Kevin


Monday - Friday,
8am - 6pm ET

Alylam Separator Triangles


Do not use GIVLAARI® (givosiran) if you have ever had a severe allergic reaction to GIVLAARI.

GIVLAARI can cause:

Severe allergic reaction

Tell your doctor or nurse right away if you experience any of the following signs or symptoms of a severe allergic reaction during treatment:

Swelling – mainly of the lips, tongue or throat which makes it difficult to swallow or breathe
  Breathing problems or wheezing
  Feeling dizzy or fainting
  Rash or hives

If you have a severe allergic reaction, your doctor or nurse will stop GIVLAARI treatment right away and you may need to take other medicines to control the symptoms.

Liver problems

Your doctor will check your liver function by doing blood tests:

Before you start using GIVLAARI
  Once a month for the first 6 months of treatment
  And when they think it is needed

If these tests show abnormal results, your doctor or nurse will decide whether to temporarily interrupt or stop treatment with GIVLAARI.

Kidney problems

Your doctor will check how your kidneys are working while you are using GIVLAARI.

Injection site reactions

GIVLAARI is given as an injection under the skin (called a “subcutaneous injection”). Reactions to this injection may happen during treatment with GIVLAARI.

Tell your doctor or nurse right away if you experience any of the following symptoms of an injection site reaction during treatment: redness, pain, itchiness, rash, discoloration, or swelling around the injection site.

Increased blood homocysteine levels

GIVLAARI may cause increased levels of homocysteine (a type of amino acid) in your blood. Your doctor will check your homocysteine levels before and during treatment by doing blood tests. If your levels are increased, your doctor may check your folate, vitamins B12 and B6, and tell you to take a vitamin B6 supplement.

What are the common side effects of GIVLAARI?

The most common side effects of GIVLAARI are nausea and injection site reactions. These are not all the possible side effects of GIVLAARI. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.


GIVLAARI is a prescription medicine used to treat acute hepatic porphyria (AHP) in adults.

For additional information about GIVLAARI, please see the full Prescribing Information.