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We Are Here to Support You

Alnylam Assist™ is committed to providing truly personalized support for you. You will have your own dedicated Case Manager to help you have a smooth treatment experience with ONPATTRO® (patisiran) and answer questions you may have along the way. It’s the support you need, when you need it.

Alnylam Assist® - Understanding Your Benefits
Understanding Benefits

Your Case Manager will thoroughly review your insurance coverage to verify benefits and help you access ONPATTRO. We encourage you to call your Case Manager with any questions you may have on an ongoing basis.

Alnylam Assist® - Financial Assistance Options
Financial Assistance Options

Alnylam Assist™ provides financial assistance options to qualifying individuals. Your Case Manager will work with you to determine eligibility.a

Alnylam Assist™ Patient Assistance Program (PAP)

 Provides ONPATTRO at no cost to eligible patients, primarily the uninsured, who meet specified financial criteria.


Alnylam Assist™ Commercial Copay Programb

Covers certain out-of-pocket costs for eligible patients with commercial insurance.

Case Managers can also provide information about other organizations that may be able to provide financial assistance.

a  Patients must meet specified eligibility criteria to qualify for assistance. Alnylam reserves the right to make eligibility determinations and to modify or discontinue any program at any time.

b  Patients with Medicare, Medicaid, or other government-sponsored insurance are not eligible for the Alnylam Assist™ Commercial Copay Program. Out-of-pocket costs for the administration of ONPATTRO will not be covered for patients residing where it is prohibited by law or where otherwise restricted.

Alnylam Assist® - Disease and Treatment Education
Disease and Treatment Education

Disease education can help you and your loved ones make more informed choices about your health. Your Case Manager can connect you with a Patient Education Liaison (PEL), a trained individual who can directly answer questions about hereditary ATTR (hATTR) amyloidosis and treatment, and provide resources and information to help you and your family learn more about this condition. PELs are employees of Alnylam Pharmaceuticals. They are not acting as healthcare providers and are not part of your healthcare team.

Introduction to Alnylam Assist

Watch this video to see all that Alnylam Assist™ has to offer.
Alnylam Assist® - Introduction Video
I’m in the patients’ corner, supporting them through challenging times. That’s why I strive to go above and beyond to service those in need.


Renae, Case Manager

Resources for You

Alnylam Assist® - Downloadable PDF

Download the Alnylam Assist™ Brochure


Alnylam Assist® - Downloadable PDF

Download the ONPATTRO Patient Brochure


Who can support me with the Alnylam Assist™ program?

When you and your doctor choose to begin treatment with ONPATTRO, you will have a personal Case Manager and access to a Patient Education Liaison (PEL). Meet your Alnylam Assist™ team ›

Alnylam Assist® - Questions Icon

Find answers to other

Frequently Asked Questions ›

Alnylam Assist® get started icon

See How to Get Started

Once you and your doctor decide to begin treatment with ONPATTRO, we'll work with your healthcare team to start the process.

How to Get Started

Alnylam Assist® Case Manager Natalie

Call Natalie


Monday - Friday,
8am - 6pm ET

Alylam Separator Triangles


What are the most important things I should know about ONPATTRO® (patisiran)?

ONPATTRO can cause:

Infusion-related reactions

ONPATTRO is given as a drip into a vein (called an “intravenous infusion”). Reactions to this infusion may happen during treatment with ONPATTRO. Before each infusion you will be given medicines that help to lower the chance of infusion-related reactions.

Tell your doctor or nurse right away if you experience any of the following signs of an infusion-related reaction during treatment:

Reddening of the face or body (flushing), skin warm
  Body aches or pain, including pain in the back, neck, or joints
  Feeling sick (nausea)
  Stomach pain
  Feeling short of breath, cough, or other breathing problems
  Chest discomfort or chest pain
  Feeling tired (fatigue)
  Rapid heart rate
  Facial swelling

If you have an infusion-related reaction, your doctor or nurse may slow down or stop your infusion, and you may need to take other medicines. When these reactions stop, or get better, your doctor or nurse may decide to start the infusion again.

Low Vitamin A levels

Treatment with ONPATTRO lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.

Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking ONPATTRO, talk to your doctor. Your doctor may refer you to an eye specialist.

What are the common side effects of ONPATTRO?

The most common side effects of ONPATTRO are respiratory infections, such as colds, sinus infections, and nasal congestion, and infusion-related reactions. These are not all the possible side effects of ONPATTRO. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.



ONPATTRO is a prescription medicine that treats the polyneuropathy caused by an illness called hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis). ONPATTRO is used in adults only.

For additional information about ONPATTRO, please see the full Prescribing Information.