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Frequently Asked Questions (FAQs)

What is Alnylam Assist™?

Alnylam Assist™ includes Case Managers, Patient Education Liaisons, and Field Reimbursement Directors who provide support to patients prescribed Alnylam therapies. This support includes: verification of insurance benefits, coverage and reimbursement education, financial assistance support for eligible patients, and disease and product education. Each member of our team is assigned to specific geographic regions to work with patients, their caregivers, healthcare providers, and insurance companies to support patients throughout treatment on ONPATTRO® (patisiran). See how Alnylam Assist™ can support you throughout treatment ›

How do I get started in the Alnylam Assist™ program?

In order to enroll in the program, you must be prescribed ONPATTRO and fill out the Start Form with your doctor. Once the form is completed and you've signed it, your doctor can submit the form online or print it out and fax it to Alnylam Assist™. Find out more about getting started ›

What support services does Alnylam Assist™ provide?

Alnylam Assist™ focuses on 3 key areas of support services for patients and their families: insurance benefit verification, financial assistance options for eligible patients, and disease and product education. Find out more about the support services offered ›

Who are Case Managers?

Case Managers are experienced in helping individuals get started on treatment and providing ongoing product support. They will tailor their method of communication to what works best for you.

An Alnylam Case Manager can help you understand your insurance coverage and options for financial support based on eligibility, as well as provide you with educational resources. Learn how you can work together with your own personal Case Manager ›

Who are Patient Education Liaisons (PELs)?

PELs have backgrounds in nursing and are experienced in educating individuals and their families about matters related to hereditary ATTR (hATTR) amyloidosis. PELs can help you in a variety of ways, including providing disease and product education, connecting you to additional resources, and answering questions about treatment. PELs are employees of Alnylam Pharmaceuticals. They are not acting as healthcare providers and are not part of your healthcare team. Learn about the PEL team and how to get connected ›

What additional resources are available?

In addition to the personalized services that are part of Alnylam Assist™, there are also educational and support resources for patients and their families. These include downloadable materials about hATTR amyloidosis and treatment, as well as links to advocacy groups that connect patients to the hATTR amyloidosis community. Find out what’s available to support you and your family ›

What if I'm a caregiver?

Alnylam Assist™ is here to support you by helping your loved one access ONPATTRO® and providing you education about hATTR amyloidosis. We can also connect you to independent organizations that can offer additional resources ›

How can I contact Alnylam Assist?

A Case Manager from Alnylam Assist™ is available from 8am - 6pm, Monday - Friday at 1-833-256-2748.

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See How to Get Started

Once you and your doctor decide to begin treatment with ONPATTRO, we'll work with your healthcare team to start the process.

How to Get Started

Alnylam Assist® Case Manager Natalie

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Monday - Friday,
8am - 6pm

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What are the most important things I should know about ONPATTRO® (patisiran)?

ONPATTRO can cause:

Infusion-related reactions

ONPATTRO is given as a drip into a vein (called an “intravenous infusion”). Reactions to this infusion may happen during treatment with ONPATTRO. Before each infusion you will be given medicines that help to lower the chance of infusion-related reactions.

Tell your doctor or nurse right away if you experience any of the following signs of an infusion-related reaction during treatment:

Reddening of the face or body (flushing), skin warm
  Body aches or pain, including pain in the back, neck, or joints
  Feeling sick (nausea)
  Stomach pain
  Feeling short of breath, cough, or other breathing problems
  Chest discomfort or chest pain
  Feeling tired (fatigue)
  Rapid heart rate
  Facial swelling

If you have an infusion-related reaction, your doctor or nurse may slow down or stop your infusion, and you may need to take other medicines. When these reactions stop, or get better, your doctor or nurse may decide to start the infusion again.

Low Vitamin A levels

Treatment with ONPATTRO lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.

Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking ONPATTRO, talk to your doctor. Your doctor may refer you to an eye specialist.

What are the common side effects of ONPATTRO?

The most common side effects of ONPATTRO are respiratory infections, such as colds, sinus infections, and nasal congestion, and infusion-related reactions. These are not all the possible side effects of ONPATTRO. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.



ONPATTRO is a prescription medicine that treats the polyneuropathy caused by an illness called hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis). ONPATTRO is used in adults only.

For additional information about ONPATTRO, please see the full Prescribing Information.