8am - 6pm ET, Monday - Friday

Frequently Asked Questions (FAQs)

What is Alnylam Assist®?

Alnylam Assist® is a comprehensive support program that offers personalized assistance to patients getting started on treatment with ONPATTRO® (patisiran), and provides ongoing support for patients and their families.

How do I enroll in the Alnylam Assist® program?

In order to enroll in the program, you must be prescribed ONPATTRO and fill out the Start Form with your doctor. Once you've signed, your doctor can submit the form online or print it out and fax it.

Who are Case Managers?

Case Managers are experienced in helping individuals get started on treatment and providing ongoing support. They will tailor their level of contact based on your personal needs. Your Alnylam Case Manager can help you understand your insurance coverage and your options for financial support that you may be eligible for as well as provide you with educational resources. You also can look to your Case Manager to provide information about infusion centers nearest to you as well as information on transitioning to home infusions if you and your doctor decide that it is right for you. Please note that home infusions may not be covered by all insurance plans. Learn how you can work together with your own personal Case Manager.

Who are Patient Education Liaisons (PELs)?

PELs have backgrounds in nursing or genetic counseling and are experienced in educating individuals and their families about matters related to hATTR amyloidosis. PELs can help you in a variety of ways, including providing disease and product education, connecting you to additional resources, and answering questions about treatment. Learn more about the PEL team and how to get connected.

Your Team

Meet the people at Alnylam Assist® who will help you during treatment.

Meet The Team

Alylam Separator Triangles

Discover More

Learn How We Can Help

Alnylam Assist® will provide you
with ongoing support.

How We Can Help

Additional Resources

Learn more about
advocacy organizations.

Connect With Others

Alnylam Assist® - Support Team
Call an Alnylam Assist® Case Manager Icon

Call Laura:


Monday - Friday, 8am - 6pm ET

Alnylam Assist® Get Started Icon

We’ll help you work with your healthcare professional to begin the process

How to Get Started

Important Safety Information

What are the most important things I should know about ONPATTRO® (patisiran)?

ONPATTRO can cause:

• Infusion-related reactions

ONPATTRO is given as a drip into a vein (called an “intravenous infusion”). Reactions to this infusion may happen during treatment with ONPATTRO. Before each infusion you will be given medicines that help to lower the chance of infusion-related reactions.

Tell your doctor or nurse right away if you experience any of the following signs of an infusion-related reaction during treatment:

• Reddening of the face or body (flushing), skin warm
• Body aches or pain, including pain in the back, neck, or joints
• Feeling sick (nausea)
• Stomach pain
• Feeling short of breath, cough, or other breathing problems
• Headache
• Chest discomfort or chest pain
• Rash
• Chills
• Dizziness
• Feeling tired (fatigue)
• Rapid heart rate
• Facial swelling


If you have an infusion-related reaction, your doctor or nurse may slow down or stop your infusion, and you may need to take other medicines. When these reactions stop, or get better, your doctor or nurse may decide to start the infusion again.

• Low Vitamin A levels

Treatment with ONPATTRO lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.

Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking ONPATTRO, talk to your doctor. Your doctor may refer you to an eye specialist.

What are the common side effects of ONPATTRO?

The most common side effects of ONPATTRO are respiratory infections, such as colds, sinus infections, and nasal congestion, and infusion-related reactions. These are not all the possible side effects of ONPATTRO. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.



ONPATTRO is a prescription medicine that treats the polyneuropathy caused by an illness called hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis). ONPATTRO is used in adults only.

For additional information about ONPATTRO, please see the full Prescribing Information.